Boobis, A. R., Ossendorp, B. C., Banasiak, U., Hamey, P. Y., Sebestyen, I., & Moretto, A.; "Cumulative risk assessment of pesticide residues in food;" Toxicology Letters, 2008, 180(2), 137-150; DOI: 10.1016/j.toxlet.2008.06.004.
There is increasing need to address the potential risks of combined exposures to multiple residues from pesticides in the diet. The available evidence suggests that the main concern is from dose addition of those compounds that act by the same mode of action. The possibility of synergy needs to be addressed on a case-by-case basis, where there is a biologically plausible hypothesis that it may occur at the levels of residues occurring in the diet. Cumulative risk assessment is a resource-intense activity and hence a tiered approach to both to... Read more