Alexander, M., Koutros, S., Bonner, M. R., Barry, K. H., Alavanja, M. C. R., Andreotti, G., Byun, H. M., Chen, L., Beane Freeman, L. E., Hofmann, J. N., Kamel, F., Moore, L. E., Baccarelli, A., & Rusiecki, J.; "Pesticide use and LINE-1 methylation among male private pesticide applicators in the Agricultural Health Study;" Environ Epigenet, 2017, 3(2), dvx005; DOI: 10.1093/eep/dvx005.
Cancer risk may be associated with DNA methylation (DNAm) levels in Long Interspersed Nucleotide Element 1 (LINE-1), a surrogate for global DNAm. Exposure to certain pesticides may increase risk of particular cancers, perhaps mediated in part through global DNAm alterations. To date, human data on pesticide exposure and global DNAm alterations are limited. The goal of this study was to e... Read more